منابع مشابه
Enzymatic synthesis of ß-lactams: Constraints and control
The constraint in synthesis of ß-lactams by penicillin acylase is the hydrolysis of the activated acyl donor and the synthetic product. The thermodynamically controlled synthesis of ß-lactams deals with direct acylation of a nucleophile (6APA, 7-ACA or 7-ADCA) by free acids in acidic pH and high concentration of solvent to achieve good yield. On the other hand, the kinetically controlled synthe...
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Understanding the antibiotic susceptibility of Salmonella enterica is important both from a clinical treatment and a public health perspective. The emergence of extended spectrum ß-lactamases (ESßLs) and AmpC ß-lactamases in S. enterica is important, as this will limit treatment options and could provide a strain with a significant selective advantage. The aim of the study was to screen isolate...
متن کاملAntibacterial and toxicological evaluation of ß-lactams synthesized by immobilized ß-lactamase-free penicillin amidase produced by Alcaligenes sp
Search for anti-ß-lactamase and synthesis of newer penicillin were suggested to overcome resistance to penicillin in chemotherapy. It was found that clavulanic acid, an ant-ß-lactamase was ineffective due to its structural modification by bacteria. Thus, there is a need for the synthesis of newer pencillins. Retro-synthesis was inspired by the success of forward reaction i.e.conversion of penic...
متن کامل2-aminoimidazoles potentiate ß-lactam antimicrobial activity against Mycobacterium tuberculosis by reducing ß-lactamase secretion and increasing cell envelope permeability
There is an urgent need to develop new drug treatment strategies to control the global spread of drug-sensitive and multidrug-resistant Mycobacterium tuberculosis (M. tuberculosis). The ß-lactam class of antibiotics is among the safest and most widely prescribed antibiotics, but they are not effective against M. tuberculosis due to intrinsic resistance. This study shows that 2-aminoimidazole (2...
متن کاملBlossoming Begets ß-spline Bases Built Better by ß-patches
The concept of symmetric recursive algorithm leads to new, sdimensional spline spaces. We present a general scheme for constructing a collection of multivariate S-splines with k-l continuous derivatives whose linear span contains all polynomials of degree at most k . This scheme is different from the one developed earlier by Dahmen and Micchelli and, independently, by Höllig, which was based on...
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ژورنال
عنوان ژورنال: Journal of Antimicrobial Chemotherapy
سال: 1988
ISSN: 1460-2091,0305-7453
DOI: 10.1093/jac/22.supplement_a.np1